In 1969, Polanski's pregnant wife, Sharon Tate, was murdered while staying at the Polanski's Benedict Canyon home above Los Angeles by members of the Manson Family. Following Tate's death, Polanski returned to Europe and spent much of his time in Paris and Gstaad, but did not make another film until he filmed Macbeth (1971) in England. The following year he went to Italy to make What? (1973) and subsequently spent the next five years living near Rome. However, he traveled to Hollywood to direct Chinatown (1974) for Paramount Pictures, with Robert Evans serving as producer. The film was nominated for eleven Academy Awards, and was a critical and box-office success; the script by Robert Towne won for Best Original Screenplay. Polanski's next film, The Tenant (1976), was shot in France, and completed the "Apartment Trilogy", following Repulsion and Rosemary's Baby.

In 1977, after a photo shoot in Los Angeles, Polanski was arrested for the sexual abuse of a 13 year old girl. He was charged with rape but pleaded guilty to unlawful sex with a minor. To avoid sentencing, Polanski fled to his home in London, but moved on to France the following day, and has had a U.S. arrest warrant outstanding since then, and an international arrest warrant since 2005.

Polanski continued to make films such as The Pianist (2002), a World War II-set adaptation of Jewish-Polish musician Władysław Szpilman's autobiography of the same name, which echoed some of Polanski's earlier life experiences. Like Szpilman, Polanski escaped the ghetto and the concentration camps while family members were killed. The film won three Academy Awards including Best Director, the Cannes Film Festival's Palme d'Or, and seven French César Awards including Best Picture and Best Director. He then released the successful films Oliver Twist (2005), To Each His Own Cinema (2007), and The Ghost Writer (2010), completed while under house arrest.

In September 2009, Polanski was arrested by Swiss police, at the request of U.S. authorities, when he traveled to receive a lifetime achievement award at the Zurich Film Festival. In October of 2009, the U.S. requested his extradition, however, on July 12, 2010, the Swiss rejected that request and instead declared him a "free man" after releasing him from custody.

Polanski attended the National Film School in Łódź, the third-largest city in Poland. In the 1950s Polanski took up acting, appearing in Andrzej Wajda's Pokolenie (A Generation, 1954) and in the same year in Silik Sternfeld's Zaczarowany rower (Enchanted Bicycle or Magical Bicycle). Polanski's directorial debut was also in 1955 with a short film Rower (Bicycle). Rower is a semi-autobiographical feature film, believed to be lost, which also starred Polanski. It refers to his real-life violent altercation with a notorious Kraków felon, Janusz Dziuba, who arranged to sell Polanski a bike, but instead beat him badly and stole his money. In real life the offender was arrested while fleeing after fracturing Polanski's skull, and executed for three murders, out of eight prior such assaults, which he had committed. Several other short films made during his study at Łódź gained him considerable recognition, particularly Two Men and a Wardrobe (1958) and When Angels Fall (1959). He graduated in 1959.

Polanski's first feature-length film, Knife in the Water (1962), was also the first significant Polish film after WWII that did not have a war theme. Scripted by Jerzy Skolimowski, Jakub Goldberg and Polanski, Knife in the Water is about a wealthy, unhappily married couple who decide to take a mysterious hitchhiker with them on a weekend boating excursion. A dark and unsettling work, Polanski's debut feature subtly evinces a profound pessimism about human relationships with regard to the psychological dynamics and moral consequences of status envy and sexual jealousy. Knife in the Water was a major commercial success in the West and gave Polanski an international reputation. The film also earned its director his first Academy Award nomination (Best Foreign Language Film, 1963).

Despite his reputation as a major Polish filmmaker, Polanski left then-communist Poland and moved to France, where he had already made two notable short films in 1961: The Fat and the Lean and Mammals. While in France, Polanski contributed one segment ("La rivière de diamants") to the French-produced omnibus film, Les plus belles escroqueries du monde (English title: The Beautiful Swindlers) in 1964. However, Polanski found that in the early 1960s the French film industry was generally unwilling to support a rising filmmaker whom they viewed as a cultural Pole and not a Frenchman.

Polanski made three feature films in England, based on original scripts written by himself and Gérard Brach, a frequent collaborator. Repulsion (1965) is a psychological horror film focusing on a young Belgian woman named Carol (Catherine Deneuve), who is living in London with her older sister (Yvonne Furneaux). While working as a beautician's assistant at a salon, Carol is often disturbed by the physical decrepitude of her elderly clients, and throughout the course of the film, she becomes increasingly distressed by sexual advances from the men around her. Her sister departs for a holiday in Italy with a boyfriend, and Carol is left alone in their shared apartment flat. Carol's disordered mind finally breaks from reality as actual threats of domestic and sexual invasion blend into grotesque paranoid hallucinations, causing her to respond with desperate, deadly acts of violence. The film's themes, situations, visual motifs, and effects clearly reflect the influence of early surrealist cinema as well as horror movies of the 1950s – particularly Luis Buñuel's Un chien Andalou, Jean Cocteau's The Blood of a Poet, Henri-Georges Clouzot's Diabolique and Alfred Hitchcock's Psycho.

Cul-de-Sac (1966) is a bleak nihilist tragicomedy filmed on location in Northumberland. The general tone and the basic premise of the film owes a great deal to Samuel Beckett's Waiting for Godot, along with aspects of Harold Pinter's The Birthday Party. Indeed, the original title for the film was When Katelbach Comes (named after the actor André Katelbach, who played the role of the master in Polanski's very Beckettian 1961 short film The Fat and the Lean), and among the cast was Jack MacGowran, a veteran of Beckett's stage and television work. The film's setup concerns two gangsters, Dickie and Albie (Lionel Stander and MacGowran), who are on the run after a heist went wrong. The film opens with Dickie pushing their broken-down car along the tidal causeway of Lindisfarne island. It is implied that the shootout which occurred during the heist had left Albie bleeding and paralyzed, and Dickie, who is also wounded but still mobile, now seeks to contact their underworld boss, Katelbach. (Like Beckett's Godot, Katelbach is frequently alluded to throughout the course of the film, but never actually appears.) As he searches the island, Dickie discovers that the famous medieval castle is inhabited by an effeminate and neurotically excitable middle-aged Englishman named George (Donald Pleasence), and his adulterous, nymphomaniacal young French wife, Teresa (Françoise Dorléac, Catherine Deneuve's older sister). A series of absurd mishaps, both farcical and tragic, ensues when Dickie decides to take the couple hostage in their castle as he waits (in vain) for further instructions from the mysterious Katelbach.

The Fearless Vampire Killers (1967) is a parody of vampire films (particularly those made by Hammer Studios) which was filmed using elaborate sets built on sound stages in London with additional location photography in the Alps (particularly Urtijëi, an Italian ski resort in the Dolomites). The plot concerns a buffoonish professor named Abronsius (Jack MacGowran) and his clumsy assistant, Alfred (played by Polanski himself), who are traveling through Transylvania in search of vampires. The two of them arrive in a small village near a vampire-infested castle, which they plan to examine. While taking lodgings at the village tavern, Alfred falls in love with Sarah, the local innkeeper's daughter (played by Polanski's future wife, Sharon Tate). Shortly after, Sarah is abducted by the vampires and taken to the castle. The rest of the film concerns Abronsius and Alfred's madcap efforts to penetrate the castle walls and rescue the girl. The ironic and macabre ending is classic Polanski. The Fearless Vampire Killers was Polanski's first feature to be photographed in color with the use of Panavision lenses (the aspect ratio is 2.35:1). The film's striking visual style, with its snow-covered, fairy-tale landscapes, recalls the work of Soviet fantasy filmmakers Aleksandr Ptushko and Alexander Row. Similarly, the richly textured, moonlit-winter-blue color schemes of the village and the snowy valleys evoke the magical, kaleidoscopic paintings of the great Russian-Jewish artist Marc Chagall, who provides the namesake for the innkeeper in the film. The film is also notable in that it features Polanski's love of winter sports, particularly skiing. In this respect The Fearless Vampire Killers recalls Polanski's 1961 short film Mammals.